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Rex Primary Care of Holly Springs

About Our Care Team

Rex Primary Care of Holly Springs, led by Christopher Byrd, M.D., Melanie Lyn Wiest, R.N., M.S.N., A.N.P.-B.C. and a comprehensive medical staff, provides complete health care for the entire family.

Schedule an Appointment

Call (919) 552-8911
Monday - Friday 8 a.m. - 5 p.m.
Closed for lunch from 12 p.m. - 1 p.m.

Christopher Byrd, M.D.

Dr. Byrd graduated from East Carolina University School of Medicine in Greenville, NC. He completed his residency and internship at Duke University Medical Center, where he was honored with the Terry Kane Award for Excellence in Family Medicine. He is board certified in family medicine and has been practicing in our community since 2002.


Melanie Lyn Wiest, RN, MSN, ANP-BC
Ms. Wiest is a certified adult nurse practitioner. Melanie received her nursing degree from Virginia Commonwealth University in Alexandria, VA and earned her master’s degree in nursing science from the University of North Carolina at Chapel Hill. During her 10 years of health care experience, Melanie has served as a clinical nursing instructor at UNC Health Care. She has a special interest in health promotion.




During regular office hours our telephone is answered by our staff. After-hours and on weekends, our answering service receives calls and forwards them to the covering board-certified family physician.

Rex Express Care of Holly Springs is available after-hours to provide treatment for ailments that don't require the full use of an emergency room.

If you are having an emergency, including chest pain, shortness of breath or abdominal pain call 911. If your need is not severe, please wait until regular office hours to contact us.

Payment & Insurance

We accept Medicaid, Medicare and most standard insurance coverage. For payment, we accept cash, checks, MasterCard® and Visa®.

Helpful Resources 

Contact Us

Rex Primary Care of Holly Springs
781 Avent Ferry Road, Suite 206
Holly Springs, NC 27540
(919) 552-8911