ado-trastuzumab emtansine

Pronunciation: AY doe tras TOOZ ue mab em TAN seen

Brand: Kadcyla

What is the most important information I should know about ado-trastuzumab emtansine?

Do not use if you are pregnant. Use effective birth control, and tell your doctor if you become pregnant during treatment.

This medicine can harm your liver. Call your doctor at once if you have upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

What is ado-trastuzumab emtansine?

Ado-trastuzumab emtansine is used to treat a HER2-positive breast cancer. This medicine is used both for early breast cancer and for breast cancer that has spread to other parts of the body (metastatic).

Ado-trastuzumab emtansine is usually given after other treatments have failed.

Kadcyla (ado-trastuzumab) should not be used in place of Herceptin (trastuzumab).

Ado-trastuzumab emtansine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving ado-trastuzumab emtansine?

You should not use ado-trastuzumab emtansine if you are allergic to it.

You may need to have a negative pregnancy test before starting this treatment.

Do not use ado-trastuzumab emtansine if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 7 months after your last dose. Tell your doctor if you become pregnant.

Tell your doctor if you have ever had:

  • heart problems;
  • liver disease (especially hepatitis B or C);
  • bleeding or blood clotting disorder such as hemophilia; or
  • asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder.

You should not breast-feed while using this medicine.

How is ado-trastuzumab emtansine given?

Ado-trastuzumab emtansine is given as an infusion into a vein. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take 30 to 90 minutes to complete.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when ado-trastuzumab emtansine is injected.

Ado-trastuzumab emtansine is usually given once every 3 weeks. Your doctor will determine how long to treat you.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your ado-trastuzumab emtansine injection.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while taking ado-trastuzumab emtansine?

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

What are the possible side effects of ado-trastuzumab emtansine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel cold, light-headed, feverish or sweaty, or have chest tightness, rapid heartbeats, or trouble breathing.

Call your doctor at once if you have:

  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • coughing up blood or vomit that looks like coffee grounds;
  • bloody or tarry stools;
  • chest pain, wheezing, dry cough, feeling short of breath;
  • unusual tiredness, feeling light-headed;
  • pale skin, cold hands and feet;
  • numbness, tingling, or burning pain in your hands or feet;
  • sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems;
  • liver problems --loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); or
  • signs of tumor cell breakdown --confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • easy bruising or bleeding (especially nosebleeds);
  • nausea, constipation;
  • joint or muscle pain;
  • headache; or
  • feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ado-trastuzumab emtansine?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect ado-trastuzumab emtansine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about ado-trastuzumab emtansine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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