Our Location

We are located on the first floor of the REX Medical Office Building, adjacent to the North Carolina Heart & Vascular Hospital.

Atrial Septal Defect

There are two types of holes which can be present between the upper chambers of the heart: an Atrial septal defect (ASD) and a patent foramen ovale (PFO.)

Atrial septal defects are present at birth. Some may close on their own, but larger defects sometime do not close on their own, allowing blood to circulate between the upper chambers, which over time can cause damage to the heart.

When blood circulates between the upper chambers of the heart, the right chambers of the heart become enlarged and can grow weaker. In addition, blood pressure in the lungs can rise, a condition called pulmonary hypertension, because of atrial septal defects.

Sometimes atrial septal defects can be associated with other congenital heart diseases, but usually they occur alone, in the absence of any other disease.

Atrial septal defects are dangerous because blood clots formed in the leg could pass through the hole between the upper chambers of the heart and get pumped to the brain, causing a stroke.

Atrial Septal DefectSymptoms of atrial septal defect

Usually, bad cases of atrial septal defects are detected in childhood and are repaired at that time. Sometimes, however, the atrial septal defects are not large enough to cause symptoms in childhood, and only become noticeable in adulthood. Typical symptoms of an atrial septal defect include the following:

  • Shortness of breath with activity or at rest
  • Heart rhythm difficulties, especially atrial fibrillation
  • Swelling in the legs or belly
  • Fatigue with activity, or declining stamina
  • More rarely, ASDs cause paradoxical emboli-blood clots that form in the leg veins can travel through the ASD and get pumped to the brain (causing a stroke), a heart artery (causing a heart attack) or to the arms or legs.

Testing for atrial septal defects

Several tests may be used to diagnose an atrial septal defect:

  • Electrocardiogram (ECG) is an electrical tracing of the heart which may have a characteristic pattern in patients with atrial septal defects.
  • Murmurs are often heard, due to increased blood flow through the lungs.
  • Chest x-ray may show evidence of enlarged right heart chambers, or enlarged pulmonary arteries
  • Echocardiography, or cardiac ultrasound, is the most common tool to diagnose atrial septal defect.
  • Sometimes a bubble study is performed with echo, where IV fluid is agitated in a syringe to create microbubbles. The IV fluid is then injected into a vein, and the bubbles can be visualized in the right chambers of the heart. If bubbles cross into the left chambers of the heart, it is suggestive of an abnormal communication between the chambers of the heart.
  • Transesophageal echocardiography is an ultrasound procedure done in the hospital. After receiving sedation to make them comfortable, patients swallow an ultrasound probe to allow close-up pictures to be taken of the heart, from the patient's esophagus. This is a similar procedure to endoscopy.

Treatments for atrial septal defects

Therapy for atrial septal defects depends on the size and location of the hole(s). For the most common defects, closure devices can be implanted through a small incision in the groin with a high degree success and very low risk of complication.

For very large defects or defects that are more complicated anatomically, surgery can effectively be used to close them.

Schedule an Appointment

For more information or to schedule an appointment with the REX Structural Heart team, call 919-784-1321.