Alert

guanidine

Pronunciation: GWAN ih deen

What is the most important information I should know about guanidine?

Guanidine can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, tiredness, mouth sores).

What is guanidine?

Guanidine is used to treat muscle weakness caused by Eaton-Lambert syndrome. Guanidine will not treat myasthenia gravis.

Guanidine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking guanidine?

You should not use guanidine if you are allergic to it.

Tell your doctor if you have ever had a weak immune system (caused by disease or by using certain medicine).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast-feed while using this medicine.

Guanidine is not approved for use by anyone younger than 18 years old.

How should I take guanidine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Guanidine doses are based on weight. Your dose needs may change if you gain or lose weight.

Guanidine can increase your risk of bleeding or infection. You will need frequent medical tests.

Your kidney function may also need to be checked.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include diarrhea, vomiting, tremors, and severe muscle spasms or twitching.

What should I avoid while taking guanidine?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What are the possible side effects of guanidine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe or ongoing stomach problems;
  • a light-headed feeling, like you might pass out;
  • painful urination, blood or pus in your urine;
  • fast or pounding heartbeats;
  • confusion, hallucinations, unusual thoughts or behavior;
  • problems with balance or muscle movement;
  • tremors; or
  • low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

  • nausea, diarrhea, stomach cramps;
  • numbness or tingling (especially in your face, hands, or feet);
  • feeling nervous or irritable;
  • abnormal liver function tests;
  • flushing (sudden warmth, redness, or tingly feeling);
  • dry mouth, upset stomach, loss of appetite;
  • sweating, rash, dry or scaly skin; or
  • redness or crusting around your hair follicles.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect guanidine?

Tell your doctor about all your other medicines, especially drugs that weaken the immune system such as cancer medicine, steroids, and medicines to prevent organ transplant rejection.

Other drugs may affect guanidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about guanidine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 3.01. Revision date: 1/24/2019.

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