Alert

moxifloxacin (oral)

Pronunciation: moxi FLOX a sin

Brand: Avelox

Avelox

slide 1 of 6, Avelox,

400 mg, oval, red, imprinted with BAYER, M400

Image of Avelox
slide 1 of 6
    

Moxifloxacin Hydrochloride

slide 2 of 6, Moxifloxacin Hydrochloride,

400 mg, oval, pink, imprinted with TEVA, 7387

Image of Moxifloxacin Hydrochloride
slide 2 of 6
    

Moxifloxacin Hydrochloride

slide 3 of 6, Moxifloxacin Hydrochloride,

400 mg, oblong, red, imprinted with BAYER, M400

Image of Moxifloxacin Hydrochloride
slide 3 of 6
    

Moxifloxacin Hydrochloride

slide 4 of 6, Moxifloxacin Hydrochloride,

400 mg, oblong, red, imprinted with BAYER, M400

Image of Moxifloxacin Hydrochloride
slide 4 of 6
    

Moxifloxacin Hydrochloride

slide 5 of 6, Moxifloxacin Hydrochloride,

400 mg, capsule, red, imprinted with E 18

Image of Moxifloxacin Hydrochloride
slide 5 of 6
    

Avelox

slide 6 of 6, Avelox,

400 mg, oblong, red, imprinted with M400, BAYER

Image of Avelox
slide 6 of 6
    

What is the most important information I should know about moxifloxacin?

Moxifloxacin can cause serious side effects, including tendon problems, nerve damage, serious mood or behavior changes, or low blood sugar.

Stop using this medicine and call your doctor at once if you have symptoms such as: headache, hunger, irritability, numbness, tingling, burning pain, confusion, agitation, paranoia, problems with memory or concentration, thoughts of suicide, or sudden pain or movement problems in any of your joints.

In rare cases, moxifloxacin may cause damage to your aorta, which could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.

What is moxifloxacin?

Moxifloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body.

Moxifloxacin is used to treat different types of bacterial infections of the skin, sinuses, lungs, or stomach.

Fluoroquinolone antibiotics can cause serious or disabling side effects that may not be reversible. Moxifloxacin should be used only for infections that cannot be treated with a safer antibiotic.

Moxifloxacin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking moxifloxacin?

You should not use this medicine if you are allergic to moxifloxacin or other fluoroquinolones (ciprofloxacin, gemifloxacin, levofloxacin, ofloxacin, norfloxacin, and others).

Moxifloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. This can happen during treatment or up to several months after you stop taking moxifloxacin. Tendon problems may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant.

Tell your doctor if you have ever had:

  • tendon problems, bone problems, arthritis, or other joint problems;
  • blood circulation problems, aneurysm, narrowing or hardening of the arteries;
  • heart problems, high blood pressure;
  • a genetic disease such as Marfan syndrome or Ehler's-Danlos syndrome;
  • diabetes;
  • a muscle or nerve disorder, such as myasthenia gravis;
  • liver or kidney disease;
  • seizures or epilepsy;
  • a head injury or brain tumor;
  • long QT syndrome (in you or a family member); or
  • low levels of potassium in your blood (hypokalemia).

Moxifloxacin is not approved for use by anyone younger than 18 years old.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

You should not breast-feed while using this medicine.

How should I take moxifloxacin?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take moxifloxacin with water, and drink extra fluids to keep your kidneys working properly.

You may take moxifloxacin with or without food, at the same time each day.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Moxifloxacin will not treat a viral infection such as the flu or a common cold.

Do not share moxifloxacin with another person.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking moxifloxacin?

Do not take moxifloxacin with dairy products such as milk or yogurt, or with calcium-fortified juice. You may eat or drink these products as part of a regular meal, but do not use them alone when taking moxifloxacin. They could make the medication less effective.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Moxifloxacin could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Tell your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.

What are the possible side effects of moxifloxacin?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Moxifloxacin can cause serious side effects, including tendon problems, side effects on your nerves (which may cause permanent nerve damage), serious mood or behavior changes (after just one dose), or low blood sugar (which can lead to coma).

Stop taking this medicine and call your doctor at once if you have:

  • low blood sugar --headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, or feeling anxious or shaky;
  • nerve symptoms in your hands, arms, legs, or feet --numbness, weakness, tingling, burning pain;
  • serious mood or behavior changes --nervousness, confusion, agitation, paranoia, hallucinations, memory problems, trouble concentrating, thoughts of suicide; or
  • signs of tendon rupture --sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions).

In rare cases, moxifloxacin may cause damage to your aorta, the main blood artery of the body. This could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.

Also stop using moxifloxacin and call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;
  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
  • muscle weakness, breathing problems;
  • a seizure (convulsions);
  • the first sign of any skin rash, no matter how mild;
  • increased pressure inside the skull --severe headaches, ringing in your ears, vision problems, pain behind your eyes; or
  • liver problems --upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • nausea, constipation, diarrhea;
  • dizziness; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect moxifloxacin?

Some medicines can make moxifloxacin much less effective when taken at the same time. If you take any of the following medicines, take your moxifloxacin dose 4 hours before or 8 hours after you take the other medicine:

  • antacids that contain magnesium or aluminum (such as Maalox, Mylanta, or Rolaids), or the ulcer medicine sucralfate (Carafate);
  • didanosine (Videx) powder or chewable tablets; or
  • vitamin or mineral supplements that contain aluminum, iron, magnesium, or zinc.

Tell your doctor about all your other medicines, especially:

  • theophylline;
  • a blood thinner (warfarin, Coumadin, Jantoven);
  • a diuretic or "water pill";
  • heart rhythm medication;
  • insulin or oral diabetes medicine (check your blood sugar regularly);
  • medicine to treat depression or mental illness;
  • steroid medicine (such as prednisone); or
  • NSAIDs (nonsteroidal anti-inflammatory drugs) --aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with moxifloxacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about moxifloxacin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 13.01. Revision date: 1/7/2019.

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