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fluoxetine and olanzapine

Pronunciation: floo OX eh teen and oh LAN za peen

Brand: Symbyax

Symbyax

slide 1 of 16, Symbyax,

25 mg-3 mg, capsule, pink/yellow, imprinted with Lilly 3230, 3/25

Image of Symbyax
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Symbyax

slide 2 of 16, Symbyax,

25 mg-6 mg, capsule, yellow, imprinted with Lilly 3231, 6/25

Image of Symbyax
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Symbyax

slide 3 of 16, Symbyax,

50 mg-12 mg, capsule, gray/red, imprinted with Lilly 3234, 12/50

Image of Symbyax
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Fluoxetine Hydrochloride-Olanzapine

slide 4 of 16, Fluoxetine Hydrochloride-Olanzapine,

25 mg-3 mg, capsule, brown, imprinted with TEVA, 5503

Image of Fluoxetine Hydrochloride-Olanzapine
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Fluoxetine Hydrochloride-Olanzapine

slide 5 of 16, Fluoxetine Hydrochloride-Olanzapine,

25 mg-6 mg, capsule, orange, imprinted with TEVA, 5504

Image of Fluoxetine Hydrochloride-Olanzapine
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Fluoxetine Hydrochloride-Olanzapine

slide 6 of 16, Fluoxetine Hydrochloride-Olanzapine,

50 mg-6 mg, capsule, white, imprinted with TEVA, 5505

Image of Fluoxetine Hydrochloride-Olanzapine
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Fluoxetine Hydrochloride-Olanzapine

slide 7 of 16, Fluoxetine Hydrochloride-Olanzapine,

25 mg-12 mg, capsule, yellow, imprinted with TEVA, 5506

Image of Fluoxetine Hydrochloride-Olanzapine
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Fluoxetine Hydrochloride-Olanzapine

slide 8 of 16, Fluoxetine Hydrochloride-Olanzapine,

50 mg-12 mg, capsule, red, imprinted with TEVA, 5507

Image of Fluoxetine Hydrochloride-Olanzapine
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Fluoxetine Hydrochloride-Olanzapine

slide 9 of 16, Fluoxetine Hydrochloride-Olanzapine,

25 mg-3 mg, capsule, buff, imprinted with TEVA, 5503

Image of Fluoxetine Hydrochloride-Olanzapine
slide 9 of 16
    

Fluoxetine Hydrochloride-Olanzapine

slide 10 of 16, Fluoxetine Hydrochloride-Olanzapine,

25 mg-6 mg, capsule, orange, imprinted with TEVA, 5504

Image of Fluoxetine Hydrochloride-Olanzapine
slide 10 of 16
    

Fluoxetine Hydrochloride-Olanzapine

slide 11 of 16, Fluoxetine Hydrochloride-Olanzapine,

50 mg-6 mg, capsule, white, imprinted with TEVA, 5505

Image of Fluoxetine Hydrochloride-Olanzapine
slide 11 of 16
    

Fluoxetine Hydrochloride-Olanzapine

slide 12 of 16, Fluoxetine Hydrochloride-Olanzapine,

25 mg-12 mg, capsule, yellow, imprinted with TEVA, 5506

Image of Fluoxetine Hydrochloride-Olanzapine
slide 12 of 16
    

Fluoxetine Hydrochloride-Olanzapine

slide 13 of 16, Fluoxetine Hydrochloride-Olanzapine,

50 mg-12 mg, capsule, maroon, imprinted with TEVA, 5507

Image of Fluoxetine Hydrochloride-Olanzapine
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Fluoxetine Hydrochloride-Olanzapine

slide 14 of 16, Fluoxetine Hydrochloride-Olanzapine,

25 mg-3 mg, capsule, orange/white, imprinted with par, 277

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Symbyax

slide 15 of 16, Symbyax,

25 mg-12 mg, capsule, red/yellow, imprinted with Lilly 3232, 12/25

Image of Symbyax
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Symbyax

slide 16 of 16, Symbyax,

50 mg-6 mg, capsule, gray/yellow, imprinted with Lilly 3233, 6/50

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What is the most important information I should know about fluoxetine and olanzapine?

You should not use this medicine if you also take pimozide or thioridazine, or if you take other medicines that contain fluoxetine or olanzapine in a non-combination form.

Do not use fluoxetine and olanzapine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Fluoxetine and olanzapine is not approved for use in older adults with dementia-related psychosis.

Fluoxetine and olanzapine is not approved for use by anyone younger than 10 years old.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

What is fluoxetine and olanzapine?

Fluoxetine is selective serotonin reuptake inhibitors (SSRI) antidepressant. Olanzapine is an antipsychotic medication.

Fluoxetine and olanzapine is a combination medicine used to treat depression caused by bipolar disorder (manic depression).

Fluoxetine and olanzapine is sometimes given after other medications have failed.

Fluoxetine and olanzapine may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking fluoxetine and olanzapine?

You should not use this medicine if you also take pimozide or thioridazine, or if you take other forms of fluoxetine or olanzapine (such as Prozac, Rapiflux, Sarafem, Selfemra, or Zyprexa).

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. Do not take an MAO inhibitor within 5 weeks after you stop taking fluoxetine and olanzapine.

Fluoxetine and olanzapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Tell your doctor if you have ever had:

  • liver disease;
  • narrow-angle glaucoma;
  • heart problems;
  • high or low blood pressure;
  • low white blood cell (WBC) counts;
  • a seizure;
  • bleeding problems;
  • breast cancer;
  • a stroke, including "mini-stroke" or "TIA";
  • diabetes, high cholesterol or triglycerides;
  • bowel obstruction, or severe constipation;
  • an enlarged prostate; or
  • trouble swallowing.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with fluoxetine and olanzapine and cause a serious condition called serotonin syndrome.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Ask your doctor about taking this medicine if you are pregnant. Taking an SSRI antidepressant during late pregnancy may cause serious medical complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Fluoxetine and olanzapine is not approved for use by anyone younger than 10 years old.

How should I take fluoxetine and olanzapine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take the medicine at the same time each day, with or without food.

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking fluoxetine and olanzapine?

Drinking alcohol can increase certain side effects of fluoxetine and olanzapine.

Avoid driving or operating machinery until you know how this medicine will affect you. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or severe drowsiness can cause falls, fractures, or other injuries.

What are the possible side effects of fluoxetine and olanzapine?

Get emergency medical help if you have signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Seek medical treatment if you have symptoms of a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, unusual bruising, or jaundice (yellowing of your skin or eyes).

High doses or long-term use of fluoxetine and olanzapine can cause a serious movement disorder that may not be reversible, especially in women and older adults. Tell your doctor right away if you have uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
  • high blood sugar --increased thirst, increased urination, hunger, fruity breath odor, confusion, upset stomach;
  • low sodium level --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; or
  • low white blood cell counts --fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects may include:

  • drowsiness;
  • increased appetite, weight gain;
  • trouble concentrating, feeling tired;
  • vision changes;
  • dry mouth;
  • swelling in your hands or feet;
  • tremor; or
  • abnormal liver function or cholesterol tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect fluoxetine and olanzapine?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Using fluoxetine and olanzapine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with fluoxetine and olanzapine may cause you to bruise or bleed easily.

Tell your doctor about all your current medicines. Many drugs can affect fluoxetine and olanzapine, especially:

  • any medicine to treat depression, anxiety, mood disorders, thought disorders, or mental illness;
  • St. John's wort;
  • tryptophan (sometimes called L-tryptophan); or
  • a blood thinner --warfarin, Coumadin, Jantoven.

This list is not complete and many other drugs may affect fluoxetine and olanzapine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about fluoxetine and olanzapine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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