Alert

decitabine

Pronunciation: de SIT a been

Brand: Dacogen

What is the most important information I should know about decitabine?

Decitabine affects your immune system. You may get infections more easily. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, cough, sore throat, trouble breathing).

What is decitabine?

Decitabine is a cancer medicine that is used to treat myelodysplastic syndromes (certain types of blood or bone marrow cancer).

Decitabine may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before receiving decitabine?

Tell your doctor if you have ever had:

  • kidney disease; or
  • liver disease.

Decitabine can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

  • If you are a woman, do not use decitabine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 2 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using decitabine.

You should not breast-feed while using decitabine.

How is decitabine given?

Decitabine is given as an infusion into a vein. A healthcare provider will give you this injection.

In most cases, a decitabine injection is given every 8 hours for 3 days. This 3-day treatment is usually repeated every 6 weeks at least 4 times.

You may be given other medications to prevent nausea or vomiting while you are receiving decitabine.

Decitabine affects your immune system. You may get infections more easily. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your decitabine injection.

What happens if I overdose?

Since decitabine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving decitabine?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

What are the possible side effects of decitabine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fever, chills, body aches, cough, sore throat, flu symptoms;
  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • pale skin, cold hands and feet;
  • slow heart rate, weak pulse, slow breathing; or
  • cough with mucus, chest pain, feeling short of breath.

Common side effects may include:

  • bruising or bleeding;
  • fever, and other signs of infection;
  • anemia, cough, trouble breathing;
  • headache, dizziness, tiredness;
  • diarrhea, constipation; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect decitabine?

Other drugs may affect decitabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about decitabine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 4.01. Revision date: 11/12/2018.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link.

Related Locations

Top