aerial view of holly springs hospital

For Greater Peace of Mind, We'll Be Here.

Now open!

Contact us at 984-960-1800.

New Hospital - Now Open

UNC REX Healthcare is excited to call Southern Wake County home and provide you and your family exceptional care with convenient access. With a state-of-the-art emergency department and birth center, expert surgical services, orthopedic care and more, you can have peace of mind knowing that when life happens, we’ll be just around the corner.

The new hospital is located at the corner of Avent Ferry Road & Highway 55 adjacent to the REX Healthcare of Holly Springs campus.

close-up image of newborn baby in blue striped hospital blanket

Birth Center

  • Private Labor & Delivery Rooms with Laboring Tubs
  • Inpatient Postpartum Beds
  • Nursery
  • C-section Room

woman in winter exercise gear sits on rock, clutching knee

Orthopedic Care

  • Joint Replacement Surgery

three women going to a run together in the park

General Surgery

  • Surgical Suite with Operating Rooms and a Procedure Room
  • Minimally Invasive Techniques
  • Da Vinci Robotic-assisted Surgery System


  • Birthing Center
  • Emergency Department with 24 Beds
    • Advanced Life Support (ALS) Transport
  • General Surgery
  • Inpatient Laboratory 
  • Inpatient Pharmacy 
  • Inpatient Medical & Surgery Floor 
  • Intermediate Care Unit
  • Imaging and Radiology 
    • Computed Tomography (CT)
    • Diagnostic Radiology 
    • Interventional Radiology 
    • Magnetic Resonance Imaging (MRI)
    • Ultrasound
    • X-ray
  • Orthopedic Care

Location & Hours

2328, 2320, 2335

Contact Information

Rex Holly Springs Hospital

Rex Holly Springs Hospital 850 S. Main St. Holly Springs, NC 27540
Get Driving Directions

  • Main Phone: 984-960-1800

Business Hours

12:00 AM - 11:59 PM
12:00 AM - 11:59 PM
12:00 AM - 11:59 PM
12:00 AM - 11:59 PM
12:00 AM - 11:59 PM
12:00 AM - 11:59 PM
12:00 AM - 11:59 PM

Now open as of November 1, 2021.

Meet Our Team