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Effective Jan. 5, 2026: Temporary Age-Based Visitor Restrictions at UNC Health for all inpatient and waiting areas throughout its inpatient hospitals.

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UNC Health Cancer Care, A Service of UNC Hospitals

UNC Health Rex at Holly Springs

As part of UNC Health Cancer Care, we offer comprehensive cancer care at several convenient locations across Wake County. Our physicians specialize in treating cancer and blood disorders. At our Holly Springs location, you’ll find expert, compassionate cancer care closer to home.

Conditions We Treat

  • Bladder cancer
  • Kidney cancer
  • Prostate cancer
  • Other urologic cancers
  • Breast cancer
  • Colorectal cancer
  • Cervical cancer
  • endocrine cancer
  • Endometrial (uterine) cancer
  • Other gynecologic cancers
  • Leukemia and lymphoma
  • Lung cancer
  • Skin cancer
  • Pancreatic cancer
  • Thyroid cancer

Services

  • Infusion 
    • Hydration and infusion of blood products
  • Laboratory
    •  Blood draws
    • Urinalysis 
  • Radiation oncology
    • Chemotherapy 
    • Intensity-modulated radiation therapy (IMRT)
    • Image-guided radiation therapy (IGRT) 
    • 3D radiation therapy
    • Surface-guided radiation therapy (SGRT)
    • Computerized tomography (CT) simulation
  • Multidisciplinary care case conferences 
  • Second opinions 
  • Hematology-oncology 
    • Consultations for cancer and blood disorders
    • Stem cell and bone marrow transplant referrals

Location & Hours

Contact Information

UNC Health Cancer Care, A Service of UNC Hospitals (UNC Health Rex at Holly Springs)

UNC Health Cancer Care, A Service of UNC Hospitals (UNC Health Rex at Holly Springs) 781 Avent Ferry Road Suite 200 Holly Springs, NC 27540
Get Driving Directions

  • Main Phone: 919-567-6135
  • Fax: 919-567-6137

Business Hours

Sunday
Closed
Monday
8:00 AM - 5:00 PM
Tuesday
8:00 AM - 5:00 PM
Wednesday
8:00 AM - 5:00 PM
Thursday
8:00 AM - 5:00 PM
Friday
8:00 AM - 5:00 PM
Saturday
Closed

Meet Our Team

Nationally Recognized Cancer Care

UNC Health providers specialize in the treatment of a variety of cancers, and many of our hospitals are accredited by the Commission on Cancer and the National Accreditation Program for Breast Centers.

UNC Lineberger Comprehensive Cancer Center

UNC Lineberger Comprehensive Cancer Center is the only public comprehensive cancer center in North Carolina and one of just 57 in the country recognized by the National Cancer Institute. Research at Lineberger leads to new and better cancer treatments that are used at UNC Health Cancer Care locations.

Clinical Trials

Clinical trials at UNC Lineberger Comprehensive Cancer Center help to advance new treatments for cancer and impact lives. You can explore clinical trials for cancer.